Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 18/20 | 1.00 |
| ▸ | MMP9 | P14780 | 18/20 | 1.00 |
| ▸ | MMP3 | P08254 | 5/20 | 0.67 |
| ▸ | MMP13 | P45452 | 3/20 | 0.67 |
| ▸ | MMP8 | P22894 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7646070 | 0.86 | MMP9 (0.74) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL7383539 | 0.82 | MMP2 (0.70) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL6813840 | 0.81 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL6446699 | 0.76 | MMP2 (0.66) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL6814140 | 0.76 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL14788892 | 0.74 | MMP9 (0.72) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL4321603 | 0.73 | MMP2 (1.00) | MMP2MMP9MMP3MMP13MMP8 | |
| Phenobarbital SCHEMBL11529160 | 0.68 | MMP9 (0.73) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL10903887 | 0.68 | MMP9 (0.55) | MMP2MMP9MMP3MMP13MMP8 | |
| SCHEMBL11143027 | 0.68 | MMP9 (0.68) | MMP2MMP9MMP3MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | claimed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | claimed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | claimed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | claimed |
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |