Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.58 |
| ▸ | SCN2B | O60939 | 2/20 | 0.46 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679932 | 0.90 | SCN9A (0.51) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL678839 | 0.87 | PPARA (0.47) | SCN9ASCN2BSCN1BSCN1A | |
| SCHEMBL678799 | 0.86 | SCN9A (0.56) | SCN9ASCN5A | |
| SCHEMBL16319447 | 0.86 | SCN9A (0.53) | SCN9ASCN5A | |
| SCHEMBL679856 | 0.85 | SCN9A (0.56) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL680374 | 0.85 | SCN9A (0.49) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL16319859 | 0.83 | MMP1 (0.56) | SCN9ASCN2BSCN1BSCN5AMAP4K4 | |
| SCHEMBL680487 | 0.82 | SCN9A (0.59) | SCN9ASCN5ACHEK2SMN1; SMN2L3MBTL1 | |
| SCHEMBL679956 | 0.81 | MAPK14 (0.55) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL679375 | 0.81 | SCN9A (0.58) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | SCN9A 13/4885SCN2B 6/4885SCN1B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.