Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680758 | 0.89 | ALDH1A1 (0.51) | MAPK14EZH2SCN3ABCL2L1MCL1 | |
| SCHEMBL679939 | 0.86 | MEN1 (0.60) | EZH2SCN3ALPAR1LPAR5BCL2L1 | |
| SCHEMBL680618 | 0.84 | MAPK14 (0.54) | MAPK14EZH2SCN3ALPAR1LPAR5 | |
| SCHEMBL680159 | 0.84 | CXCL8 (0.59) | SCN3ALPAR1LPAR5BCL2L1MCL1 | |
| SCHEMBL680489 | 0.84 | SCN3A (0.45) | SCN3ALPAR1LPAR5BCL2L1MCL1 | |
| SCHEMBL680374 | 0.84 | SCN9A (0.49) | BCL2L1MCL1SCN2BSCN1ASCN1B | |
| SCHEMBL680346 | 0.84 | SCN9A (0.57) | BCL2L1MCL1SCN2BSCN1ASCN1B | |
| SCHEMBL678839 | 0.83 | PPARA (0.47) | P4HTMSCN2BSCN1ASCN1BSCN9A | |
| SCHEMBL680062 | 0.83 | MMP13 (0.47) | P4HTMSCN2BSCN1ASCN1BSCN9A | |
| SCHEMBL680203 | 0.82 | SCN3A (0.45) | SCN3ABCL2L1MCL1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |
| US-20120010207-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010207-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MAPK14 1576/4885EZH2 4401/4885SCN3A 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.