Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 7/20 | 0.41 |
| ▸ | RXRB | P28702 | 7/20 | 0.41 |
| ▸ | RXRG | P48443 | 7/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934 | 0.92 | FFAR4 (0.46) | HDAC1HDAC8PPARGPPARDPPARA | |
| SCHEMBL6630 | 0.90 | HDAC1 (0.40) | HDAC1HDAC8PPARGPPARDPPARA | |
| SCHEMBL7466 | 0.88 | LPAR1 (0.47) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6857 | 0.86 | LPAR1 (0.42) | PPARGPPARDPPARANR1H2NR1H3 | |
| SCHEMBL6878 | 0.86 | PTGES (0.37) | HDAC1HDAC8HDAC6MAPT | |
| SCHEMBL6082 | 0.86 | HDAC1 (0.34) | HDAC1HDAC8PPARGPPARDPPARA | |
| SCHEMBL6543 | 0.86 | HDAC1 (0.40) | HDAC1HDAC8HDAC6FFAR4MAPT | |
| SCHEMBL1403 | 0.86 | LPAR1 (0.41) | HDAC1HDAC8LPAR1HDAC6MAPT | |
| SCHEMBL7176 | 0.82 | HDAC1 (0.37) | HDAC1HDAC8PPARGPPARDPPARA | |
| SCHEMBL1859 | 0.82 | KCNA3 (0.37) | HDAC1HDAC8LPAR1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |