SCHEMBL6878

SCHEMBL6878

Cc1noc(-c2ccc(-c3ccc(C#CC(=O)O)cc3)cc2)c1N(C)CCCc1cccc(C(F)(F)F)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGES O14684 1/20 0.37
FFAR1 O14842 3/20 0.36
HDAC1 Q13547 4/20 0.35
HDAC8 Q9BY41 3/20 0.35
HDAC6 Q9UBN7 2/20 0.35
ALDH1A1 P00352 1/20 0.34
TACR1 P25103 2/20 0.34
BRD4 O60885 1/20 0.34
MAPT P10636 2/20 0.34
FAAH O00519 1/20 0.34
KMT2A Q03164 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
SERPINE1 P05121 1/20 0.34
HDAC3 O15379 2/20 0.34
HDAC2 Q92769 2/20 0.34
PTPRC P08575 1/20 0.34
PTPN2 P17706 1/20 0.34
PTPN1 P18031 1/20 0.34
PTPN6 P29350 1/20 0.34
PTPN9 P43378 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7176 0.91 HDAC1 (0.37) PTGESHDAC1HDAC8HDAC6ALDH1A1
SCHEMBL6811 0.86 HDAC1 (0.42) HDAC1HDAC8HDAC6MAPT
SCHEMBL6934 0.86 FFAR4 (0.46) FFAR1HDAC1HDAC8HDAC6ALDH1A1
SCHEMBL1403 0.83 LPAR1 (0.41) HDAC1HDAC8HDAC6ALDH1A1TACR1
SCHEMBL6630 0.82 HDAC1 (0.40) HDAC1HDAC8HDAC6ALDH1A1MAPT
SCHEMBL6082 0.82 HDAC1 (0.34) HDAC1HDAC8HDAC6ALDH1A1TACR1
SCHEMBL6543 0.81 HDAC1 (0.40) FFAR1HDAC1HDAC8HDAC6ALDH1A1
SCHEMBL1859 0.79 KCNA3 (0.37) HDAC1HDAC8HDAC6ALDH1A1MAPT
SCHEMBL13720116 0.79 PTGES (0.39) PTGESFFAR1HDAC1HDAC8HDAC6
SCHEMBL14727 0.79 PTGES (0.39) PTGESFFAR1HDAC1HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP claimed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO claimed
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed