SCHEMBL7176

SCHEMBL7176

CCOC(=O)C#Cc1ccc(-c2ccc(-c3onc(C)c3N(C)CCCc3cccc(C(F)(F)F)c3)cc2)cc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 6/20 0.37
HDAC6 Q9UBN7 6/20 0.37
HDAC8 Q9BY41 4/20 0.37
MAPT P10636 3/20 0.37
KMT2A Q03164 3/20 0.35
TDP1 Q9NUW8 1/20 0.35
MEN1 O00255 2/20 0.35
HDAC5 Q9UQL6 2/20 0.35
NPC1 O15118 2/20 0.34
USP2 O75604 1/20 0.34
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
ALOX15 P16050 1/20 0.34
CYP2C19 P33261 1/20 0.34
ALDH1A1 P00352 1/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6878 0.91 PTGES (0.37) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL6630 0.86 HDAC1 (0.40) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL6543 0.85 HDAC1 (0.40) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL1859 0.83 KCNA3 (0.37) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL6811 0.82 HDAC1 (0.42) HDAC1HDAC6HDAC8MAPTPPARG
SCHEMBL6934 0.81 FFAR4 (0.46) HDAC1HDAC6HDAC8ALDH1A1THRB
SCHEMBL11897090 0.81 HDAC1 (0.36) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL14736 0.80 MAPT (0.36) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL1403 0.79 LPAR1 (0.41) HDAC1HDAC6HDAC8MAPTKMT2A
SCHEMBL6082 0.78 HDAC1 (0.34) HDAC1HDAC6HDAC8MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed