Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.35 |
| ▸ | SELE | P16581 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817004 | 0.90 | HSD17B10 (0.35) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL7062988 | 0.86 | MPO (0.41) | MPOCYSLTR1NPC1RAB9ATP53 | |
| SCHEMBL6817014 | 0.86 | MPO (0.42) | MPOCYSLTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6816998 | 0.83 | MPO (0.41) | MPOCYSLTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6811895 | 0.83 | MPO (0.41) | MPOCYSLTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6811772 | 0.83 | EDNRA (0.48) | MPOCYSLTR1NPC1RAB9ATP53 | |
| SCHEMBL6812788 | 0.83 | EDNRA (0.51) | MPOCYSLTR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6812158 | 0.82 | MPO (0.44) | MPOCYSLTR1TP53ICAM1SELE | |
| SCHEMBL6812674 | 0.82 | MPO (0.40) | MPOCYSLTR1PKMALDH1A1KDM4E | |
| SCHEMBL6811954 | 0.81 | MPO (0.44) | MPOCYSLTR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040248953-A1 | 3-Arylsulfanyl and 3-heteroarylsulfanyl substituted benzo[b]thiophenes as therapeutic agents | GOGLIOTTI ROCCO DEAN (US) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248953-A1 | 3-Arylsulfanyl and 3-heteroarylsulfanyl substituted benzo[b]thiophenes as therapeutic agents | SULT2A1, SULT1A1, SULT1E1 | MPO 3227/4885CYSLTR1 45/4885NPC1 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.