Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 2/20 | 0.49 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BCL6 | P41182 | 3/20 | 0.46 |
| ▸ | BCOR | Q6W2J9 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6813581 | 0.86 | MEN1 (0.52) | KMT2AMEN1PKMBCL6BCOR | |
| SCHEMBL6392629 | 0.80 | PRKD3 (0.62) | KMT2AMEN1ROCK1ALDH1A1KDM4E | |
| SCHEMBL6813901 | 0.79 | PRKD3 (0.51) | KMT2AMEN1ROCK1KDM4ESMN1; SMN2 | |
| SCHEMBL6813325 | 0.79 | MAPT (0.52) | ROCK1SMN1; SMN2CDK2CDK5EGFR | |
| SCHEMBL6813273 | 0.79 | PRKD3 (0.48) | PTK6ERBB2ROCK1GAACDK2 | |
| SCHEMBL6810391 | 0.77 | MEN1 (0.51) | PTK6KMT2AMEN1PKMERBB2 | |
| SCHEMBL6818104 | 0.77 | ALDH1A1 (0.44) | KMT2AMEN1PKMROCK1ALDH1A1 | |
| SCHEMBL6814222 | 0.77 | HSP90AA1 (0.46) | KMT2AMEN1PKMBCL6BCOR | |
| SCHEMBL20569889 | 0.76 | PRKD3 (0.54) | KMT2AMEN1BCL6BCORROCK1 | |
| SCHEMBL6397413 | 0.76 | KIF11 (0.56) | PTK6KIF11KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017384-B1 | AZABENZIMIDAZOLE-BASED COMPOUNDS FOR MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION | ZENTARIS GMBH (DE) | 2004-11-10 | — | — | EP | disclosed |