Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 14/20 | 0.44 |
| ▸ | ACE | P12821 | 9/20 | 0.43 |
| ▸ | CAD | P27708 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814128 | 1.00 | MME (0.44) | MMEACECADECE1KDM4E | |
| SCHEMBL6501628 | 1.00 | MME (0.44) | MMEACECADECE1KDM4E | |
| SCHEMBL4903224 | 0.98 | MME (0.46) | MMEACECADECE1KDM4E | |
| SCHEMBL18576543 | 0.98 | MME (0.46) | MMEACECADECE1KDM4E | |
| SCHEMBL15134405 | 0.98 | MME (0.46) | MMEACECADECE1KDM4E | |
| SCHEMBL20367630 | 0.98 | MME (0.46) | MMEACECADECE1KDM4E | |
| SCHEMBL630497 | 0.94 | CAD (0.43) | MMEACECAD | |
| SCHEMBL3625069 | 0.94 | CAD (0.43) | MMEACECAD | |
| SCHEMBL2344195 | 0.94 | CAD (0.43) | MMEACECAD | |
| SCHEMBL3258686 | 0.88 | FKBP5 (0.52) | MMEACEECE1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054996-B1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | SEARLE & CO (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6638758-B2 | Separating enantiomeric lactam esters by selective hydrolyzing one enantiomer by contact with a biocatalyst, such as an enzyme or a microorganism and separating the hydrolysis product from the unreacted lactam esters. | G.D. SEARLE & CO. | 2003-10-28 | — | — | US | disclosed |
| US-20010055798-A1 | Process for the enzymatic resolution of lactams | G.D. SEARLE & CO. | 2001-12-27 | — | — | US | disclosed |
| US-6277626-B1 | LACTAM ESTERS ARE CONTACTED WITH A BIOCATALYST, SUCH AS ENZYME OR A MICROORGANISM, IN SOLUTION WHEREIN ONLY ONE ENANTIOMER IS SELECTIVELY HYDROLYZED TO GIVE OPTICALLY ACTIVE ISOMER OF CORRESPONDING ACID; SEPARATING HYDROLYSIS PRODUCT | G.D. SEARLE & CO. | 2001-08-21 | — | — | US | disclosed |
| EP-1054996-A1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | G.D. SEARLE & CO. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041405-A1 | PROCESS FOR THE ENZYMATIC RESOLUTION OF LACTAMS | G.D. SEARLE & CO. (US) | 1999-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010055798-A1 | Process for the enzymatic resolution of lactams | MGAM, SRR, APEH | MME 613/4885ACE 69/4885CAD 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.