Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680169 | 1.00 | MEN1 (0.38) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL680790 | 0.87 | MEN1 (0.38) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL681295 | 0.87 | MEN1 (0.38) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL681616 | 0.85 | ALDH1A1 (0.54) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL680168 | 0.85 | ALDH1A1 (0.54) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL12188597 | 0.84 | BRD4 (0.40) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL683331 | 0.84 | BRD4 (0.40) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL681313 | 0.84 | MEN1 (0.37) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL681578 | 0.84 | MEN1 (0.37) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 | |
| SCHEMBL2738604 | 0.83 | MEN1 (0.39) | MEN1ALDH1A1THRBKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |