Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680168 | 1.00 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL681022 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL681451 | 0.87 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL680169 | 0.85 | MEN1 (0.38) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL681350 | 0.85 | MEN1 (0.38) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL683328 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL684169 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL681578 | 0.84 | MEN1 (0.37) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL681313 | 0.84 | MEN1 (0.37) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB | |
| SCHEMBL12194481 | 0.81 | SLC6A9 (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |