Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593284 | 0.88 | KCNN4 (0.53) | SMN1; SMN2HTTGAACYP2C19POLB | |
| SCHEMBL6813620 | 0.81 | HPGD (0.46) | SMN1; SMN2HTTRAB9ACYP2C19HPGD | |
| SCHEMBL6810533 | 0.78 | PTPRB (0.44) | SMN1; SMN2RAB9AHPGDKCNN4NPC1 | |
| SCHEMBL29220422 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2HTTGAARAB9AGLA | |
| SCHEMBL4015143 | 0.76 | KCNN4 (0.53) | SMN1; SMN2HTTGAACYP2C19POLB | |
| SCHEMBL6818662 | 0.76 | HDAC3 (0.49) | SMN1; SMN2HTTGAARAB9AHPGD | |
| SCHEMBL19858735 | 0.74 | RAB9A (0.45) | SMN1; SMN2HTTGAARAB9AGLA | |
| SCHEMBL3191632 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AHPGDPOLBALDH1A1 | |
| SCHEMBL10951249 | 0.74 | ALDH1A1 (0.50) | SMN1; SMN2HTTPOLBALDH1A1TSHR | |
| SCHEMBL7715181 | 0.73 | ALDH1A1 (0.67) | SMN1; SMN2HTTCYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153015-B1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| CN-1147481-C | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | - | 2004-04-28 | — | — | CN | disclosed |
| CN-1339028-A | Pyrimidine-2,4,6-triones as inhibitors of matrix metalloproteinases | HOFFMANN LA ROCHE (CH) | 2002-03-06 | — | — | CN | disclosed |
| EP-1153015-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| US-6265578-B1 | MATRIX METALLOPROTEASE INHIBITORS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2000047565-A1 | PYRIMIDINE-2,4,6-TRIONES AS INHIBITORS OF MATRIX METALLOPROTEINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-08-17 | — | — | WO | disclosed |