SCHEMBL6813836

SCHEMBL6813836

CC1=C(C#CC(C)(C)C)c2cc(/C=C/c3ccc(C(=O)O)cc3)ccc2C(C)(C)C1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARA P10276 18/20 0.51
RARB P10826 19/20 0.50
RARG P13631 19/20 0.50
RXRA P19793 4/20 0.50
NR2E1 Q9Y466 1/20 0.50
CYP26A1 O43174 2/20 0.38
CYP3A4 P08684 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
GMNN O75496 1/20 0.38
USP2 O75604 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38
CYP2D6 P10635 1/20 0.38
NFKB1 P19838 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6813842 1.00 RARA (0.51) RARARARBRARGRXRANR2E1
SCHEMBL6814451 0.89 PTPN1 (0.42) RARARARBRARGRXRANR2E1
SCHEMBL6814443 0.89 PTPN1 (0.42) RARARARBRARGRXRANR2E1
SCHEMBL6813834 0.84 RXRA (0.49) RARARARBRARGRXRACYP26A1
SCHEMBL8028156 0.81 RARA (0.60) RARARARBRARGRXRANR2E1
SCHEMBL6813827 0.80 RARA (0.74) RARARARBRARGRXRANR2E1
SCHEMBL6813830 0.80 RARA (0.74) RARARARBRARGRXRANR2E1
SCHEMBL6814439 0.73 RARB (0.37) RARARARBRARGRXRACYP26A1
SCHEMBL8026328 0.72 RARA (0.72) RARARARBRARGRXRANR2E1
SCHEMBL7046911 0.71 RARA (0.56) RARARARBRARGRXRANR2E1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230042181-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2023-02-09 US disclosed
US-11447831-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists SYROS PHARMACEUTICALS, INC. (US) 2022-09-20 US disclosed
US-20210285059-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS SYROS PHARMACEUTICALS, INC. 2021-09-16 US disclosed
US-11053552-B2 Methods of stratifying patients for treatment with retinoic acid receptor-α agonists SYROS PHARMACEUTICALS, INC. (US) 2021-07-06 US disclosed
US-20200392583-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2020-12-17 US disclosed
US-10697025-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists SYROS PHARMACEUTICALS, INC. (US) 2020-06-30 US disclosed
US-20190249259-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2019-08-15 US disclosed
US-10240210-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists SYROS PHARMACEUTICALS, INC. (US) 2019-03-26 US disclosed
US-20180187271-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2018-07-05 US disclosed
US-20180187271-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2018-07-05 US disclosed
US-9868994-B2 Methods of stratifying patients for treatment with retinoic acid receptor-α agonists SYROS PHARMACEUTICALS, INC. (US) 2018-01-16 US disclosed
US-9868994-B2 Methods of stratifying patients for treatment with retinoic acid receptor-α agonists SYROS PHARMACEUTICALS, INC. (US) 2018-01-16 US disclosed
US-9845508-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists SYROS PHARMACEUTICALS, INC. (US) 2017-12-19 US disclosed
US-9845508-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists SYROS PHARMACEUTICALS, INC. (US) 2017-12-19 US disclosed
US-20170292165-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2017-10-12 US disclosed
US-20170292165-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2017-10-12 US disclosed
US-20160355888-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2016-12-08 US disclosed
US-20160355888-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS OXFORD FINANCE LLC, AS COLLATERAL AGENT 2016-12-08 US disclosed
EP-1115687-B1 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2004-05-26 EP disclosed
US-6194601-B1 USEFUL IN TREATMENT OF SKIN DISORDERS SUCH AS ACNE AND DAMAGE FROM AGE OR IRRADIATION; CHRONIC SKIN INFLAMMATORY INFLAMMATORY DISEASES SUCH AS PSORIASIS AND ATOPIC DERMATITIS; ANTITUMOR AGENTS FOR BREAST CANCER, LUNG CANCER; NONTOXIC BRISTOL-MYERS SQUIBB COMPANY 2001-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210285059-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-20180187271-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-10240210-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-10697025-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-20200392583-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-20190249259-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-11053552-B2 Methods of stratifying patients for treatment with retinoic acid receptor-α agonists RARA, RARB, RARG RARA 1/4885RARB 2/4885RARG 3/4885
US-20160355888-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-11447831-B2 Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-20170292165-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885
US-20230042181-A1 METHODS OF STRATIFYING PATIENTS FOR TREATMENT WITH RETINOIC ACID RECEPTOR-ALPHA AGONISTS RARA, RARG, RARB RARA 1/4885RARB 3/4885RARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.