Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 6/20 | 0.40 |
| ▸ | RARB | P10826 | 6/20 | 0.39 |
| ▸ | RARG | P13631 | 6/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814443 | 1.00 | PTPN1 (0.42) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL6813836 | 0.89 | RARA (0.51) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6813842 | 0.89 | RARA (0.51) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6814439 | 0.85 | RARB (0.37) | RARARARBRARGRXRAMAPT | |
| SCHEMBL8028178 | 0.82 | PTPN1 (0.50) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL6810956 | 0.81 | RARA (0.59) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL6810960 | 0.81 | RARA (0.59) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL8771845 | 0.78 | PTPN1 (0.52) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL8771839 | 0.78 | PTPN1 (0.52) | PTPN1RARARARBRARGRXRA | |
| SCHEMBL6814374 | 0.75 | RARA (0.42) | PTPN1RARARARBRARGRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115687-B1 | 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-1115687-A4 | 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2002-06-05 | — | — | EP | disclosed |
| EP-1115687-A1 | 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6194601-B1 | USEFUL IN TREATMENT OF SKIN DISORDERS SUCH AS ACNE AND DAMAGE FROM AGE OR IRRADIATION; CHRONIC SKIN INFLAMMATORY INFLAMMATORY DISEASES SUCH AS PSORIASIS AND ATOPIC DERMATITIS; ANTITUMOR AGENTS FOR BREAST CANCER, LUNG CANCER; NONTOXIC | BRISTOL-MYERS SQUIBB COMPANY | 2001-02-27 | — | — | US | disclosed |
| WO-2000017147-A1 | 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-30 | — | — | WO | disclosed |