Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 4/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29956517 | 0.73 | MAP3K14 (0.41) | CRBNMAP3K14LMNANPC1 | |
| SCHEMBL19438354 | 0.70 | CRBN (0.52) | CRBNTP53KMT2ANPSR1NR2F2 | |
| SCHEMBL28109850 | 0.70 | CRBN (0.46) | CRBNTP53KMT2ANPSR1NR2F2 | |
| SCHEMBL24111511 | 0.70 | CRBN (0.46) | CRBNTP53KMT2ANPSR1NR2F2 | |
| SCHEMBL15922671 | 0.70 | — | — | |
| SCHEMBL4756282 | 0.70 | ITGB1 (0.39) | CRBNMAP3K14ALDH1A1ITGB3ITGB2 | |
| SCHEMBL630436 | 0.70 | ITGB1 (0.54) | CRBNTP53KMT2ANPSR1NR2F2 | |
| SCHEMBL27009963 | 0.68 | BRD4 (0.31) | — | |
| SCHEMBL12270577 | 0.68 | NR2F2 (0.47) | CRBNTP53KMT2ANPSR1NR2F2 | |
| SCHEMBL6966145 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-8957056-B2 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTIUTE FOR CANCER RESEARCH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957056-B2 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTIUTE FOR CANCER RESEARCH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8835693-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835693-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-09-16 | — | — | US | disclosed |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-01-09 | — | — | US | disclosed |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-01-09 | — | — | US | disclosed |
| US-8324284-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-12-04 | — | — | US | disclosed |
| US-8324284-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-12-04 | — | — | US | disclosed |
| US-8202911-B2 | Migrastatin analog compositions and uses thereof | CORNELL RESEARCH FOUNDATION, INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20090054488-A1 | Isomigrastatin Analogs In The Treatment Of Cancer | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| US-20090054488-A1 | Isomigrastatin Analogs In The Treatment Of Cancer | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| US-20070037783-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
| US-20070037783-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037783-A1 | Migrastatin analogs and uses thereof | FOXM1, MTX1, C3AR1 | CRBN 3154/4885TP53 2122/4885KMT2A 1763/4885 |
| US-20090054488-A1 | Isomigrastatin Analogs In The Treatment Of Cancer | EDNRB, KDR, IGF1R | CRBN 2678/4885TP53 649/4885KMT2A 4456/4885 |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | MTX1, MTNR1B, MTNR1A | CRBN 3295/4885TP53 1967/4885KMT2A 1915/4885 |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | KDR, MTX1, FOXM1 | CRBN 2312/4885TP53 2081/4885KMT2A 1979/4885 |
| US-20140011844-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | KDR, HMGCR, LPAR3 | CRBN 2072/4885TP53 2331/4885KMT2A 2284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.