Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819280 | 0.90 | LMNA (0.52) | MEN1KMT2AGAASMN1; SMN2MAOB | |
| SCHEMBL6816530 | 0.90 | MAPT (0.59) | MEN1KMT2AGAASMN1; SMN2LMNA | |
| SCHEMBL6816140 | 0.90 | MAPT (0.63) | MEN1KMT2AGAASMN1; SMN2MAOB | |
| SCHEMBL6814990 | 0.89 | MAPT (0.60) | MEN1KMT2AGAASMN1; SMN2MAOB | |
| SCHEMBL6815637 | 0.89 | LMNA (0.53) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6819815 | 0.88 | MAPT (0.50) | MEN1KMT2AGAASMN1; SMN2HDAC1 | |
| SCHEMBL6816400 | 0.88 | HDAC1 (0.56) | MEN1KMT2AGAASMN1; SMN2HDAC1 | |
| SCHEMBL6815834 | 0.88 | LMNA (0.63) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6819712 | 0.87 | ALDH1A1 (0.60) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6811359 | 0.87 | THRB (0.55) | MEN1KMT2AGAASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137632-B1 | THIOUREA INHIBITORS OF HERPES VIRUSES | WYETH CORP (US) | 2004-07-28 | — | — | EP | disclosed |
| EP-1137645-B1 | ALPHA-METHYLBENZYL-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A PHENYLENEDIAMINE GROUP | WYETH CORP (US) | 2004-05-26 | — | — | EP | disclosed |