SCHEMBL6815448

SCHEMBL6815448

CC1C2=CC(=O)CCN2c2ccccc2C1C

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 8/20 0.45
AADAT Q8N5Z0 1/20 0.38
DDB1 Q16531 1/20 0.35
CRBN Q96SW2 1/20 0.35
MGLL Q99685 1/20 0.35
MAPT P10636 1/20 0.33
DRD2 P14416 2/20 0.33
DRD4 P21917 2/20 0.33
ATM Q13315 1/20 0.33
CREBBP Q92793 1/20 0.33
NOTUM Q6P988 1/20 0.33
GAA P10253 1/20 0.32
GFER P55789 1/20 0.32
KMT2A Q03164 1/20 0.32
OPRM1 P35372 1/20 0.32
OPRK1 P41145 1/20 0.32
OPRL1 P41146 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6820238 0.81 SRD5A1 (0.62) SRD5A1KMT2A
SCHEMBL6819931 0.80 SRD5A1 (0.63) SRD5A1KMT2A
SCHEMBL6820470 0.75 SRD5A1 (0.67) SRD5A1NOTUM
SCHEMBL6820083 0.75 SRD5A1 (0.69) SRD5A1DDB1CRBNMGLLMAPT
SCHEMBL6815740 0.73 AADAT (0.38) SRD5A1AADATNOTUMOPRM1OPRK1
SCHEMBL6822913 0.72 SRD5A1 (0.48) SRD5A1AADATDDB1CRBNMGLL
SCHEMBL6820284 0.63 SRD5A1 (0.74) SRD5A1AADATNOTUM
SCHEMBL2470207 0.63 AADAT (0.50) AADATMAPTGAAKMT2A
SCHEMBL6819781 0.62 SRD5A1 (1.00) SRD5A1AADATNOTUM
SCHEMBL6820061 0.62 SRD5A1 (0.71) SRD5A1OPRM1OPRK1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1102765-B1 PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES APPLIED RESEARCH SYSTEMS (AN) 2003-09-17 EP claimed
US-6723850-B1 N-ALKYLATION OF THE THIOAMIDE WITH A VINYL KETONE IN PRESENCE OF A STRONG BASE; 6-CHLORO-(1H)-3,4-DIHYDROQUINOLIN-2-THIONE REACTED WITH ETHYL VINYL KETONE APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2004-04-20 US disclosed
EP-1102765-B1 PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES APPLIED RESEARCH SYSTEMS (AN) 2003-09-17 EP disclosed
EP-1102765-A1 PROCESS FOR THE SYNTHESIS OF (1$i(H))-BENZO C]QUINOLIZIN-3-ONES DERIVATIVES Applied Research Systems ARS Holding N.V. (AN) 2001-05-30 EP disclosed
WO-2000008019-A1 PROCESS FOR THE SYNTHESIS OF (1H)-BENZO[C]QUINOLIZIN-3-ONES DERIVATIVES APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) 2000-02-17 WO disclosed