Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.45 |
| ▸ | PDE4A | P27815 | 9/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6231255 | 0.89 | CASP1 (0.55) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL14027108 | 0.89 | CASP1 (0.48) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL6826307 | 0.88 | CASP1 (0.54) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL5703639 | 0.86 | PDE4B (0.50) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL5498111 | 0.85 | CASP1 (0.49) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL6826506 | 0.84 | CASP1 (0.50) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL8483972 | 0.82 | PDE4A (0.49) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL3167378 | 0.82 | CASP1 (0.47) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL14027109 | 0.82 | CASP1 (0.47) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL7355456 | 0.81 | PDE4A (0.51) | PDE4BPDE4APDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200388-A4 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6740765-B1 | DECARBOXYLATING DIESTER | SMITHKLINE BEECHAM CORPORATION | 2004-05-25 | — | — | US | disclosed |
| EP-1200388-A1 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SmithKline Beecham Corporation (US) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001010817-A1 | METHOD FOR PREPARING CYCLOHEXANE CARBOXYLIC ACIDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-15 | — | — | WO | disclosed |