Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12167817 | 0.85 | ADRB2 (0.51) | ADRB2ADRB1ADRB3AOC3RAB9A | |
| SCHEMBL12104118 | 0.83 | ADRB2 (0.52) | ADRB2ADRB1ADRB3AOC3RAB9A | |
| SCHEMBL681686 | 0.83 | ALDH1A1 (0.43) | ADRB2ADRB1ADRB3ALDH1A1HPGD | |
| SCHEMBL17803795 | 0.83 | ADRB2 (0.43) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL680095 | 0.83 | ADRB2 (0.43) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL2739003 | 0.82 | ADRB2 (0.51) | ADRB2ADRB1ADRB3AOC3RAB9A | |
| SCHEMBL680060 | 0.81 | ADRB2 (0.44) | ADRB2ADRB1ADRB3MEN1KMT2A | |
| SCHEMBL681545 | 0.81 | L3MBTL1 (0.40) | RAB9AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL681135 | 0.81 | L3MBTL1 (0.40) | RAB9AMEN1KMT2AALDH1A1POLB | |
| SCHEMBL681680 | 0.81 | L3MBTL1 (0.40) | RAB9AMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |