Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681322 | 0.84 | AOC3 (0.41) | POLB | |
| SCHEMBL679725 | 0.84 | ALOX5 (0.41) | PYCR1ALOX5CYP1A2KMT2AMEN1 | |
| SCHEMBL12194484 | 0.84 | AOC3 (0.41) | POLB | |
| SCHEMBL684691 | 0.83 | CYP1A2 (0.42) | PYCR1ALOX5CYP1A2KMT2AMEN1 | |
| SCHEMBL2738812 | 0.81 | ALOX5 (0.47) | PYCR1ALOX5CYP1A2KMT2AMEN1 | |
| SCHEMBL681415 | 0.78 | CHRM2 (0.43) | PYCR1ALOX5CYP1A2OPRM1 | |
| SCHEMBL681194 | 0.77 | LSS (0.40) | PYCR1ALOX5CYP1A2KMT2AMEN1 | |
| SCHEMBL680150 | 0.77 | HTR2A (0.43) | ALOX5CYP1A2KMT2A | |
| SCHEMBL12193966 | 0.76 | POLB (0.35) | ALOX5CYP1A2POLBOPRD1 | |
| SCHEMBL680223 | 0.74 | ALOX5 (0.42) | PYCR1ALOX5CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |