Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017110 | 0.92 | P2RX4 (0.34) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9017112 | 0.92 | P2RX4 (0.34) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8464960 | 0.92 | KMT2A (0.39) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9017132 | 0.92 | P2RX4 (0.35) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8464962 | 0.92 | KMT2A (0.39) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9017053 | 0.90 | P2RX1 (0.39) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9017057 | 0.86 | KMT2A (0.36) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9017056 | 0.86 | KMT2A (0.36) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8464656 | 0.85 | P2RX4 (0.48) | P2RX4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8464658 | 0.85 | P2RX4 (0.48) | P2RX4PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014986-B1 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT 1 BETA ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-07-14 | — | — | EP | claimed |
| EP-1021183-B1 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-1014985-B1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A H5-HT 1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2003-05-21 | — | — | EP | claimed |
| EP-1000048-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-27 | — | — | EP | claimed |
| US-20010051626-A1 | 8-(Piperidin-4-yl- or piperazin-1-yl)-2-substituted-tetralin derivatives; selective effect at a subgroup of 5-hydroxy-tryptamine receptors, h5-HT1B receptors (previously 5-HT1D beta); antagonists; mood disorders, antianxiolytic | ASTRAZENECA AB (SE) | 2001-12-13 | — | — | US | claimed |
| US-6313118-B1 | HYDROXYTRYPTAMINE RECEPTOR ANTAGONISTS | ASTRA AKTIEBOLAG (SE) | 2001-11-06 | — | — | US | claimed |
| US-6159970-A | Combination of a monoamine oxidase inhibitor and a h5-HT1B antagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | claimed |
| US-6159972-A | Combination of a selective 5-HT1A antagonist and a selective ub. h5-HT.s1B antagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | claimed |
| US-6159971-A | Combination of a 5-HT reuptake inhibitor and a h5-HT1B anatagonist or partial agonist | ASTRAZENECA AB (SE) | 2000-12-12 | — | — | US | claimed |
| EP-0714602-B1 | Sulphonylaminophenyluracil herbicides for paddy field | BAYER AGROCHEM KK (JP) | 1999-05-12 | — | — | EP | claimed |
| US-5641725-A | Sulphonylaminophenyluracil herbicides for paddy field | NIHON BAYER AGROCHEM K.K. (JP) | 1997-06-24 | — | — | US | claimed |
| EP-0714602-A1 | Sulphonylaminophenyluracil herbicides for paddy field | NIHON BAYER AGROCHEM K.K. (JP) | 1996-06-05 | — | — | EP | claimed |
| EP-1258193-B1 | Herbicidal compositions of tetrazolinone herbicides and antidotes therefor | SYNGENTA LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| EP-1014986-B1 | A COMBINATION OF A MONOAMINE OXIDASE INHIBITOR AND A h5-HT 1 BETA ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-07-14 | — | — | EP | disclosed |
| EP-1021183-B1 | A COMBINATION OF A SELECTIVE 5-HT1A ANTAGONIST AND A SELECTIVE h5-HT1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1014985-B1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A H5-HT 1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2003-05-21 | — | — | EP | disclosed |
| EP-0714602-A1 | Sulphonylaminophenyluracil herbicides for paddy field | NIHON BAYER AGROCHEM K.K. (JP) | 1996-06-05 | — | — | EP | disclosed |
| US-5466660-A | Tetrazolinones as herbicides for use in paddy | NIHON BAYER AGROCHEM K.K. (JP) | 1995-11-14 | — | — | US | disclosed |
| US-5347010-A | Tetrzolinone herbicides | NIHON BAYER AGROCHEM K.K. (JP) | 1994-09-13 | — | — | US | disclosed |
| EP-0578090-A2 | Tetrazolinones as herbicides for use in a rice paddy | NIHON BAYER AGROCHEM K.K. (JP) | 1994-01-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051626-A1 | 8-(Piperidin-4-yl- or piperazin-1-yl)-2-substituted-tetralin derivatives; selective effect at a subgroup of 5-hydroxy-tryptamine receptors, h5-HT1B receptors (previously 5-HT1D beta); antagonists; mood disorders, antianxiolytic | HTR1D, HTR1F, HTR2C | P2RX4 612/4885PDE4A 4473/4885PDE4B 4330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.