Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819213 | 0.92 | MEN1 (0.39) | MAPTLMNAS1PR4SMN1; SMN2ALPG | |
| SCHEMBL6817723 | 0.90 | CRHR1 (0.38) | MAPTLMNAS1PR4SMN1; SMN2ALPG | |
| SCHEMBL6818521 | 0.89 | MAPT (0.44) | MAPTLMNASMN1; SMN2ALPGTDP1 | |
| SCHEMBL6818033 | 0.87 | MAPT (0.43) | MAPTLMNASMN1; SMN2TDP1NPC1 | |
| SCHEMBL6817921 | 0.85 | MAPT (0.36) | MAPTLMNAS1PR4SMN1; SMN2ALPG | |
| SCHEMBL6818822 | 0.85 | MAPT (0.39) | MAPTLMNASMN1; SMN2ALDH1A1PDE5A | |
| SCHEMBL6817700 | 0.84 | MAPT (0.35) | MAPTLMNAS1PR4SMN1; SMN2ALPG | |
| SCHEMBL6817889 | 0.83 | MAPT (0.40) | MAPTLMNAS1PR4SMN1; SMN2NPC1 | |
| SCHEMBL6818369 | 0.82 | S1PR4 (0.37) | MAPTLMNAS1PR4SMN1; SMN2ALPG | |
| SCHEMBL6081726 | 0.82 | S1PR4 (0.39) | MAPTLMNAS1PR4SMN1; SMN2ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004031189-A1 | PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2004-04-15 | — | — | WO | disclosed |