Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1RN | P18510 | 3/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.52 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | CPA1 | P15085 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.44 |
| ▸ | ACACB | O00763 | 4/20 | 0.44 |
| ▸ | YAP1 | P46937 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817956 | 1.00 | IL1RN (0.52) | IL1RNERAP2ERAP1TSHRPPARG | |
| SCHEMBL6817238 | 0.91 | ACE (0.54) | PPARGMMEACECPA1ACE2 | |
| SCHEMBL6817237 | 0.91 | ACE (0.54) | PPARGMMEACECPA1ACE2 | |
| SCHEMBL6818126 | 0.90 | GAA (0.57) | IL1RNERAP2ERAP1TSHRALDH1A1 | |
| SCHEMBL6818123 | 0.90 | GAA (0.57) | IL1RNERAP2ERAP1TSHRALDH1A1 | |
| SCHEMBL6818133 | 0.84 | CYP3A4 (0.44) | PPARGACACBLMNA | |
| SCHEMBL5392194 | 0.80 | ITGB3 (0.64) | PPARGALDH1A1GAARAB9A | |
| SCHEMBL5392187 | 0.80 | ITGB3 (0.64) | PPARGALDH1A1GAARAB9A | |
| SCHEMBL6813705 | 0.79 | ACACB (0.57) | PPARGMMEACECPA1ACE2 | |
| SCHEMBL6813707 | 0.79 | ACACB (0.57) | PPARGMMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1211359-C | Novel phenylalkoxy-phenyl derivatives | ASTRAZENECA AB (SE) | 2005-07-20 | — | — | CN | disclosed |
| EP-1237857-B1 | NEW PHENALKYLOXY-PHENYL DERIVATIVES | ASTRAZENECA AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| US-6630509-B2 | Pharmaceutical medication associated with insulin resistance; patient with prophylaxis conditions having reduced sensitivity to insulin | ASTRAZENECA AB (SE) | 2003-10-07 | — | — | US | disclosed |
| CN-1433401-A | Novel phenylalkoxy-phenyl derivatives | ASTRAZENECA AB (SE) | 2003-07-30 | — | — | CN | disclosed |
| US-20030018207-A1 | Phenalkyloxy-phenyl derivatives | ASTRAZENECA AB (SE) | 2003-01-23 | — | — | US | disclosed |
| EP-1237857-A1 | NEW PHENALKYLOXY-PHENYL DERIVATIVES | AstraZeneca AB (SE) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001040170-A1 | NEW PHENALKYLOXY-PHENYL DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018207-A1 | Phenalkyloxy-phenyl derivatives | GPR119, INSR, IAPP | IL1RN 1522/4885ERAP2 1070/4885ERAP1 1410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.