Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | NOS1 | P29475 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196105 | 0.86 | NCF1 (0.83) | NCF1ALDH1A1HTTKDM4EHPGD | |
| Bromide SCHEMBL6818319 | 0.84 | PRMT6 (0.61) | ALDH1A1HTTKDM4EHRH3SMN1; SMN2 | |
| Bromide SCHEMBL27780447 | 0.80 | NCF1 (0.64) | NCF1ALDH1A1HTTKDM4EHPGD | |
| Bromide SCHEMBL6813605 | 0.79 | HRH3 (0.69) | NCF1ALDH1A1HPGDNOS1HRH3 | |
| SCHEMBL23182936 | 0.78 | NCF1 (0.71) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL15189005 | 0.78 | NCF1 (0.66) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL110388 | 0.78 | NCF1 (1.00) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL22711383 | 0.78 | NCF1 (0.71) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL264786 | 0.78 | NCF1 (0.71) | NCF1ALDH1A1HTTKDM4EHPGD | |
| SCHEMBL807251 | 0.78 | NCF1 (0.66) | NCF1ALDH1A1HTTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224364-A1 | Organo-zinc compounds | RIEKE METALS, INC. | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224364-A1 | Organo-zinc compounds | ZFX, CXXC5, CXXC4 | NCF1 195/4885ALDH1A1 2237/4885HTT 3806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.