SCHEMBL6818370

SCHEMBL6818370

O=C(O)c1cc(Br)ccc1NC(=O)c1onc2ccc(S(=O)(=O)Cl)cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 2/20 0.44
AKR1C2 P52895 3/20 0.42
AKR1C1 Q04828 3/20 0.42
AKR1C4 P17516 1/20 0.42
AKR1C3 P42330 1/20 0.42
ALB P02768 1/20 0.41
STING1 Q86WV6 1/20 0.40
KCNK2 O95069 1/20 0.39
KCNK10 P57789 1/20 0.39
TDP1 Q9NUW8 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ACLY P53396 1/20 0.38
KDM1A O60341 1/20 0.38
MAPT P10636 2/20 0.38
SLC10A6 Q3KNW5 2/20 0.38
POLB P06746 1/20 0.38
MEN1 O00255 1/20 0.38
ABL1 P00519 1/20 0.38
TSHR P16473 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6818553 0.88 AKR1C2 (0.50) AKR1C2AKR1C1AKR1C4AKR1C3ALB
SCHEMBL6819170 0.87 MEN1 (0.44) METAP2AKR1C2AKR1C1AKR1C4AKR1C3
SCHEMBL6822703 0.85 ALB (0.48) ALBSTING1
SCHEMBL6833965 0.85 ALB (0.54) ALBTDP1KDM4EMAPTPOLB
SCHEMBL6818060 0.82 AKR1C2 (0.51) AKR1C2AKR1C1AKR1C4AKR1C3STING1
SCHEMBL6817877 0.79 GRIK1 (0.46) METAP2AKR1C2AKR1C1AKR1C4AKR1C3
SCHEMBL6814346 0.78 ALB (0.42) AKR1C2AKR1C1AKR1C4AKR1C3ALB
SCHEMBL6813659 0.77 IP6K1 (0.38) TDP1KDM4EPOLBMEN1KMT2A
SCHEMBL6833908 0.75 CA1 (0.45) METAP2AKR1C2AKR1C1AKR1C4AKR1C3
SCHEMBL6830706 0.74 ALDH1A1 (0.43) TDP1KDM4EMAPTSLC10A6POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018428-A1 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed