Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.48 |
| ▸ | MERTK | Q12866 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432402 | 0.85 | TRPV4 (0.54) | MAPTVCAM1MERTKKMT2AMEN1 | |
| SCHEMBL224136 | 0.83 | VCAM1 (0.54) | MAPTVCAM1MERTKKMT2AMEN1 | |
| SCHEMBL31432638 | 0.83 | MAPT (0.53) | MAPTVCAM1MERTKKMT2AMEN1 | |
| SCHEMBL31431100 | 0.82 | MAPT (0.59) | MAPTVCAM1MERTKKMT2AMEN1 | |
| SCHEMBL6549707 | 0.79 | VCAM1 (0.47) | MAPTVCAM1MERTKKMT2AMEN1 | |
| SCHEMBL15170403 | 0.78 | AR (0.45) | MAPTTRPV4 | |
| SCHEMBL23628998 | 0.78 | MAOB (0.51) | MAPTVCAM1KMT2AMEN1NPC1 | |
| SCHEMBL7070030 | 0.78 | MAPT (0.53) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22897608 | 0.78 | MAPT (0.42) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31441975 | 0.78 | MAPT (0.42) | MAPTKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191934-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0929302-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-31 | — | — | EP | disclosed |
| EP-1191934-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | disclosed |
| WO-2000076516-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0929302-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |