SCHEMBL224136

SCHEMBL224136

COc1cc(C#N)ccc1[N+](=O)[O-]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 2/20 0.54
ALDH1A1 P00352 3/20 0.51
TDP1 Q9NUW8 1/20 0.51
LMNA P02545 1/20 0.50
MAPT P10636 3/20 0.49
SIRT6 Q8N6T7 1/20 0.48
MERTK Q12866 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
ESRRA P11474 1/20 0.46
AR P10275 3/20 0.45
HTT P42858 1/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
EGFR P00533 1/20 0.43
KDM4E B2RXH2 1/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
PRKDC P78527 1/20 0.42
HSD17B10 Q99714 1/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1939464 0.87 VCAM1 (0.58) VCAM1ALDH1A1TDP1MAPTMERTK
SCHEMBL2725343 0.85 ALDH1A1 (0.53) ALDH1A1TDP1LMNAMAPTSIRT6
SCHEMBL16952936 0.83 ALDH1A1 (0.51) ALDH1A1TDP1LMNAMAPTSIRT6
SCHEMBL6818591 0.83 MAPT (0.50) VCAM1ALDH1A1TDP1LMNAMAPT
SCHEMBL20575299 0.83 VCAM1 (0.50) VCAM1TDP1LMNAMAPTMERTK
SCHEMBL31432402 0.83 TRPV4 (0.54) VCAM1ALDH1A1LMNAMAPTMERTK
SCHEMBL31432638 0.80 MAPT (0.53) VCAM1ALDH1A1LMNAMAPTMERTK
SCHEMBL7371195 0.80 VCAM1 (0.54) VCAM1ALDH1A1TDP1MAPTESRRA
SCHEMBL15174209 0.80 VCAM1 (0.50) VCAM1TDP1MAPTMERTKMEN1
SCHEMBL31431100 0.79 MAPT (0.59) VCAM1ALDH1A1LMNAMAPTMERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101362701-A 2-amino-5-hydroxypropiophenone preparation method UNIV FUDAN (CN) 2009-02-11 CN claimed
WO-2024120471-A1 COMPOUNDS TARGETING MUTANT OF P53 JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2024-06-13 WO disclosed
WO-2024099226-A1 BIPHENYL HETEROARYL-CONTAINING DIHYDROPTERIDINONE DERIVATIVE, AND USE THEREOF 沈阳药科大学 2024-05-16 WO disclosed
EP-2507243-B1 SPIROINDOLINONE PYRROLIDINES HOFFMANN LA ROCHE (CH) 2015-06-10 EP disclosed
EP-1781640-B1 2,4-DI(AMINOPHENYL)PYRIMIDINE DERIVATIVES AS PLK INHIBITORS BOEHRINGER INGELHEIM INT (DE) 2015-01-07 EP disclosed
EP-2564850-B1 Polo-like kinase inhibitors TAKEDA PHARMACEUTICAL (JP) 2014-08-13 EP disclosed
EP-2205241-B1 POLO-LIKE KINASE INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2014-05-21 EP disclosed
US-8642657-B2 4-(methyl sulfonyl amino) phenyl analogues as vanilloid antagonist showing excellent analgesic activity and the pharmaceutical compositions comprising the same GRUENENTHAL GMBH (DE) 2014-02-04 US disclosed
US-8318727-B2 Polo-like kinase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-11-27 US disclosed
EP-2507243-A1 SPIROINDOLINONE PYRROLIDINES F. Hoffmann-La Roche AG (CH) 2012-10-10 EP disclosed
WO-2001029022-A1 BENZOPYRAN DERIVATIVES RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) 2001-04-26 WO disclosed
US-6150379-A BLOOD COAGULATION FACTOR XA INHIBITORS; TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE ACTIVITY; THROMBOLYTIC AND ISCHEMIC AGENTS; E.G., 2-(6-(5-AMIDINO-1H-BENZIMIDAZOL-2-YL)-PYRID-3-YLCARBONYLAMINO)-3 -HYDROXYBUTYRIC ACID AXYS PHARMACEUTICALS, INC. (US) 2000-11-21 US disclosed
WO-1999026932-A1 BY AMIDINO GROUP SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTICOAGULANTS AXYS PHARMACEUTICALS, INC. (US) 1999-06-03 WO disclosed
WO-1999026941-A1 SUBSTITUTED AMIDINOARYL DERIVATIVES AND THEIR USE AS ANTICOAGULANTS AXYS PHARMACEUTICALS, INC. (US) 1999-06-03 WO disclosed
EP-0729457-B1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PROD (US) 1998-12-23 EP disclosed
US-5840764-A SMOOTH MUSCLE RELAXANTS FOR TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME AMERICAN HOME PRODUCTS CORPORATION (US) 1998-11-24 US disclosed
WO-1998033763-A1 SUBSTITUTED HYDROXY-ANILINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-08-06 WO disclosed
EP-0729457-A1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-09-04 EP disclosed
US-5506252-A MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-09 US disclosed
WO-1995014005-A1 DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS AMERICAN HOME PRODUCTS CORPORATION (US) 1995-05-26 WO disclosed