Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | F13A1 | P00488 | 1/20 | 0.57 |
| ▸ | ACACB | O00763 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263240 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KDM4EF13A1ACACBALDH1A1 | |
| SCHEMBL7438653 | 0.81 | CYP4F2 (0.46) | SMN1; SMN2KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10592850 | 0.80 | KDM4E (0.84) | SMN1; SMN2KDM4EF13A1ACACBALDH1A1 | |
| SCHEMBL7486468 | 0.80 | TAAR1 (0.46) | SMN1; SMN2KDM4EALDH1A1HPGDBLM | |
| SCHEMBL7151292 | 0.78 | POLB (0.49) | SMN1; SMN2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL14431407 | 0.77 | KDM4E (0.68) | SMN1; SMN2KDM4EF13A1ALDH1A1LMNA | |
| SCHEMBL6249295 | 0.77 | POLB (0.49) | SMN1; SMN2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL7393169 | 0.77 | RAB9A (0.57) | SMN1; SMN2MAPT | |
| SCHEMBL9331570 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EF13A1ACACBALDH1A1 | |
| SCHEMBL6821960 | 0.76 | FFAR1 (0.52) | SMN1; SMN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |