Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699556 | 0.90 | MAPT (0.49) | ROCK2ROCK1KDM4EMMP13MAPT | |
| SCHEMBL6818722 | 0.90 | MMP13 (0.43) | ROCK2ROCK1KDM4EMMP13MAPT | |
| SCHEMBL6818728 | 0.83 | MMP13 (0.52) | ROCK2ROCK1KDM4EMMP13MEN1 | |
| SCHEMBL6704369 | 0.69 | MEN1 (0.50) | KDM4EMMP13MAPTMEN1KMT2A | |
| SCHEMBL6699569 | 0.69 | MMP13 (0.57) | ROCK2ROCK1KDM4EMMP13MAPT | |
| SCHEMBL5696971 | 0.67 | MMP13 (0.65) | MMP13 | |
| SCHEMBL6705173 | 0.67 | MMP13 (0.52) | KDM4EMMP13MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6819276 | 0.67 | GRIN1 (0.42) | KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL6698254 | 0.67 | MEN1 (0.52) | ROCK2ROCK1MMP13MAPTMEN1 | |
| SCHEMBL6814152 | 0.66 | MEN1 (0.37) | KDM4EMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014916-A1 | PYRIMIDINE FUSED BICYCLIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |