Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818733 | 0.90 | ROCK2 (0.46) | MMP13ROCK2ROCK1MEN1MAPT | |
| SCHEMBL6699556 | 0.89 | MAPT (0.49) | MMP13ROCK2ROCK1MEN1MAPT | |
| SCHEMBL6818728 | 0.80 | MMP13 (0.52) | MMP13ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL5696971 | 0.69 | MMP13 (0.65) | MMP13 | |
| SCHEMBL6704369 | 0.69 | MEN1 (0.50) | MMP13MEN1MAPTKMT2AKDM4E | |
| SCHEMBL6699569 | 0.68 | MMP13 (0.57) | MMP13ROCK2ROCK1MEN1MAPT | |
| SCHEMBL6814146 | 0.67 | FPR1 (0.38) | MEN1MAPTKMT2AHTTSMN1; SMN2 | |
| SCHEMBL6705173 | 0.67 | MMP13 (0.52) | MMP13MEN1KMT2AKDM4EHTT | |
| SCHEMBL6698254 | 0.66 | MEN1 (0.52) | MMP13ROCK2ROCK1MEN1MAPT | |
| SCHEMBL7986413 | 0.66 | HTT (0.52) | HTTSMN1; SMN2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014916-A1 | PYRIMIDINE FUSED BICYCLIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |