Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 3/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28181773 | 0.98 | TDP1 (0.42) | HTR2AHRH1TDP1LMNACHRM2 | |
| SCHEMBL9513844 | 0.80 | HTR2A (0.45) | HTR2AHRH1TDP1LMNACHRM2 | |
| SCHEMBL7509241 | 0.76 | SLC22A2 (0.38) | OPRM1OPRK1KDM4ESLC22A2SLC22A3 | |
| SCHEMBL18324641 | 0.71 | HTR2A (0.44) | HTR2AHRH1TDP1LMNACHRM2 | |
| SCHEMBL11393827 | 0.69 | KDM4E (0.46) | HTR2AHRH1TDP1KDM4EAOC3 | |
| SCHEMBL4269275 | 0.68 | HTR2A (0.45) | HTR2AHRH1TDP1LMNACHRM2 | |
| SCHEMBL2252400 | 0.68 | HTR2A (0.44) | HTR2AHRH1TDP1LMNACHRM2 | |
| SCHEMBL5498181 | 0.68 | SIGMAR1 (0.51) | HTR2AHRH1TDP1LMNACHRM2 | |
| Hydrochloric Acid SCHEMBL5497858 | 0.67 | SIGMAR1 (0.50) | HTR2AHRH1TDP1LMNACHRM2 | |
| Hydrochloric Acid SCHEMBL27764173 | 0.67 | TDP1 (0.46) | HTR2AHRH1TDP1LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1178805-A4 | NOVEL SYNTHESIS AND CRYSTALLIZATION OF PIPERAZINE RING-CONTAINING COMPOUNDS | TEVA PHARMA (IL) | 2004-11-24 | — | — | EP | disclosed |
| EP-1178805-A1 | NOVEL SYNTHESIS AND CRYSTALLIZATION OF PIPERAZINE RING-CONTAINING COMPOUNDS | Teva Pharmaceutical Industries Limited (IL) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000062782-A1 | NOVEL SYNTHESIS AND CRYSTALLIZATION OF PIPERAZINE RING-CONTAINING COMPOUNDS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2000-10-26 | — | — | WO | disclosed |
| US-4254031-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1981-03-03 | — | — | US | disclosed |
| US-4217452-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1980-08-12 | — | — | US | disclosed |
| US-4025513-A | Synthesis for the preparation of tetracyclic compounds | AKZONA INCORPORATED (US) | 1977-05-24 | — | — | US | disclosed |