Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513477 | 0.81 | HTR2A (0.47) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| SCHEMBL13060870 | 0.81 | HTR2A (0.57) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| SCHEMBL6820428 | 0.80 | HTR2A (0.42) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| Hydrochloric Acid SCHEMBL7625519 | 0.80 | AOC3 (0.41) | HTR2AHRH1TDP1LMNATSHR | |
| SCHEMBL19471218 | 0.79 | POLB (0.37) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| SCHEMBL8133703 | 0.79 | HTR2A (0.45) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| SCHEMBL9514760 | 0.79 | CARM1 (0.47) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| SCHEMBL7981758 | 0.79 | OPRM1 (0.46) | HTR2AHRH1OPRM1OPRD1TDP1 | |
| Hydrochloric Acid SCHEMBL28181773 | 0.79 | TDP1 (0.42) | HTR2AHRH1OPRM1TDP1LMNA | |
| SCHEMBL5100202 | 0.76 | OPRM1 (0.65) | HTR2AHRH1OPRM1OPRD1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333938-B1 | 2-HYDROXY-3-ARYLOXY-PROPYLAMINE DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1993-04-14 | — | — | EP | disclosed |
| US-5047425-A | Amine derivatives having cardiovascular activity | SIMES SOCIETA ITALIANA MEDICINALI & SINTETICI SPA (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0333938-A1 | 2-Hydroxy-3-aryloxy-propylamine derivatives having cardiovascular activity | ZAMBON GROUP S.p.A. (IT) | 1989-09-27 | — | — | EP | disclosed |