Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 4/20 | 0.50 |
| ▸ | CTSS | P25774 | 2/20 | 0.50 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14418794 | 0.82 | ALDH1A1 (0.52) | HSPA5ALDH1A1CTSKMETAP1L3MBTL1 | |
| SCHEMBL2513951 | 0.81 | ALDH1A1 (0.46) | HSPA5ALDH1A1METAP1SMN1; SMN2HSPA2 | |
| SCHEMBL2659403 | 0.81 | CTSK (0.55) | CTSKCTSSFFAR2METAP1 | |
| SCHEMBL12228038 | 0.81 | CTSK (0.55) | CTSKCTSSFFAR2METAP1 | |
| SCHEMBL7384478 | 0.81 | HSPA5 (0.62) | HSPA5FFAR2METAP1L3MBTL1HSPA2 | |
| SCHEMBL7385636 | 0.81 | HSPA5 (0.62) | HSPA5ALDH1A1CTSKCTSSMETAP1 | |
| SCHEMBL6826168 | 0.81 | PSEN1 (0.53) | CTSKCTSS | |
| SCHEMBL7382573 | 0.80 | METAP1 (0.52) | HSPA5ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6824738 | 0.80 | PSEN1 (0.53) | CTSKCTSSFFAR2SMN1; SMN2 | |
| SCHEMBL5128729 | 0.79 | PSEN1 (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040152747-A1 | Thiazole compounds for treatment of neurodegenerative disorders | PFIZER INC | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152747-A1 | Thiazole compounds for treatment of neurodegenerative disorders | APP, PARK7, IAPP | HSPA5 1208/4885ALDH1A1 590/4885CYP1A2 3772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.