Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.51 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817879 | 0.97 | CTSL (0.70) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL6947217 | 0.95 | CTSL (0.72) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL6820572 | 0.95 | CTSL (0.72) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL6817663 | 0.95 | CTSL (0.72) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL8110131 | 0.95 | CTSL (0.72) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL8204168 | 0.95 | CTSL (0.72) | CTSLADORA3ADORA1YTHDC1HDAC1 | |
| SCHEMBL6817775 | 0.93 | CTSL (0.59) | CTSLADORA3ADORA1YTHDC1CDK1 | |
| SCHEMBL6945264 | 0.89 | CTSL (0.56) | CTSLADORA3ADORA1YTHDC1CDK1 | |
| SCHEMBL6817730 | 0.88 | CTSL (0.54) | CTSLADORA3ADORA1CDK1FLT3 | |
| SCHEMBL6818080 | 0.88 | ADORA3 (0.61) | CTSLADORA3ADORA1YTHDC1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056745-B1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMA INC (US) | 2004-06-16 | — | — | EP | disclosed |
| CN-1128149-C | 6,9-Disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines | AVENTIS PHARMA INC (US) | 2003-11-19 | — | — | CN | disclosed |
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |
| EP-1056745-A2 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043676-A2 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |