Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.35 |
| ▸ | GRK6 | P43250 | 3/20 | 0.35 |
| ▸ | ULK1 | O75385 | 3/20 | 0.33 |
| ▸ | IGF1R | P08069 | 2/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.31 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | STK16 | O75716 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | GRK5 | P34947 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820104 | 0.88 | AURKA (0.38) | AURKAGRK6IGF1RCTNNB1TCF7L2 | |
| SCHEMBL6823211 | 0.86 | ULK1 (0.46) | AURKAULK1PDK1ULK2 | |
| SCHEMBL6819540 | 0.84 | IRAK4 (0.32) | ULK1IGF1RSYKDAPK3JAK2 | |
| SCHEMBL6823194 | 0.83 | NPY5R (0.46) | AURKAULK1PDK1ULK2 | |
| SCHEMBL6820543 | 0.82 | NTRK1 (0.39) | ULK1PAK4 | |
| SCHEMBL6819621 | 0.82 | NTRK1 (0.39) | GRK6ULK1IGF1RPAK4PDK1 | |
| SCHEMBL6819632 | 0.81 | ULK1 (0.38) | ULK1PAK4PDK1ULK2 | |
| SCHEMBL6820537 | 0.81 | ULK1 (0.35) | ULK1PAK4PDK1ULK2 | |
| SCHEMBL3769795 | 0.81 | AURKA (0.35) | AURKAGRK6ULK1IGF1RCTNNB1 | |
| SCHEMBL6820523 | 0.80 | IGF1R (0.43) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |