Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823194 | 0.97 | NPY5R (0.46) | ULK1NPY5RPDK1ULK2SOS1 | |
| SCHEMBL6819632 | 0.91 | ULK1 (0.38) | ULK1NPY5RPDK1ULK2SOS1 | |
| SCHEMBL6819621 | 0.90 | NTRK1 (0.39) | ULK1NPY5RPDK1ULK2SOS1 | |
| SCHEMBL6820543 | 0.90 | NTRK1 (0.39) | ULK1SRCGSK3BNTRK1 | |
| SCHEMBL6820537 | 0.89 | ULK1 (0.35) | ULK1NPY5RPDK1ULK2NTRK1 | |
| SCHEMBL6820767 | 0.86 | AURKA (0.35) | ULK1PDK1ULK2AURKA | |
| SCHEMBL6823151 | 0.84 | IGF1R (0.40) | — | |
| SCHEMBL6819540 | 0.84 | IRAK4 (0.32) | ULK1 | |
| SCHEMBL6816711 | 0.83 | AURKA (0.42) | ULK1NPY5RSOS1AURKASRC | |
| SCHEMBL2204246 | 0.83 | ULK1 (0.57) | ULK1NPY5RPDK1ULK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |