Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.38 |
| ▸ | TRIM58 | Q8NG06 | 4/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | NPR1 | P16066 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823211 | 0.91 | ULK1 (0.46) | ULK1PDK1ULK2NPY5RSOS1 | |
| SCHEMBL6820543 | 0.89 | NTRK1 (0.39) | ULK1PAK4 | |
| SCHEMBL6820537 | 0.89 | ULK1 (0.35) | ULK1PDK1ULK2PAK4NPY5R | |
| SCHEMBL6823194 | 0.88 | NPY5R (0.46) | ULK1PDK1ULK2NPY5RSOS1 | |
| SCHEMBL6820504 | 0.85 | TRIM58 (0.37) | TRIM58PAK4NPY5RSOS1 | |
| SCHEMBL6820499 | 0.85 | TRIM58 (0.37) | ULK1TRIM58PAK4NPY5RNPR1 | |
| SCHEMBL6819621 | 0.84 | NTRK1 (0.39) | ULK1PDK1ULK2PAK4NPY5R | |
| SCHEMBL6819540 | 0.82 | IRAK4 (0.32) | ULK1PAK4 | |
| SCHEMBL3767946 | 0.82 | ULK1 (0.40) | ULK1TRIM58PDK1ULK2PAK4 | |
| SCHEMBL6820767 | 0.81 | AURKA (0.35) | ULK1PDK1ULK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037814-A1 | INDAZOLINONE COMPOSITIONS USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-05-06 | — | — | WO | disclosed |