Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818169 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MTNR1AMTNR1BPOLBMEN1 | |
| SCHEMBL1731363 | 0.80 | GAA (0.53) | ALDH1A1POLBTSHRPKMMCOLN3 | |
| SCHEMBL5707095 | 0.74 | MTNR1A (0.69) | ALDH1A1MTNR1AMTNR1BTSHRTRPV1 | |
| SCHEMBL6171639 | 0.74 | ALDH1A1 (0.78) | ALDH1A1POLBMEN1KMT2ATSHR | |
| SCHEMBL27737992 | 0.73 | ALDH1A1 (0.50) | ALDH1A1POLBTSHRPKM | |
| SCHEMBL6674123 | 0.73 | ALDH1A1 (0.58) | ALDH1A1MEN1KMT2ATSHRPKM | |
| SCHEMBL6818574 | 0.73 | SMN1; SMN2 (0.52) | ALDH1A1POLB | |
| SCHEMBL13783457 | 0.73 | ALDH1A1 (0.55) | ALDH1A1TSHRPKMMCOLN3 | |
| SCHEMBL6821062 | 0.73 | ALDH1A1 (0.58) | ALDH1A1MTNR1AMTNR1BPOLBMEN1 | |
| SCHEMBL6821024 | 0.71 | PPID (0.44) | ALDH1A1MEN1KMT2ATSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050646-A1 | 1, 2, 5-THIADIAZOLIDIN-3-ONE 1, 1 DIOXIDE DERIVATIVES AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE PTP1B | ASTRAZENECA AB (SE) | 2004-06-17 | — | — | WO | disclosed |