Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822009 | 0.87 | ADORA1 (0.45) | ADORA1MAPK1IGF1RMAPK3MAPK14 | |
| SCHEMBL7039587 | 0.85 | ADORA1 (0.57) | ADORA1MAPK1IGF1RMAPK3MAPK14 | |
| SCHEMBL6818544 | 0.85 | ADORA1 (0.46) | ADORA1MAPK1IGF1RPDE1APDE1B | |
| SCHEMBL6821959 | 0.85 | ADORA1 (0.42) | ADORA1MAPK1IGF1RPDE1APDE1B | |
| SCHEMBL6822033 | 0.84 | ADORA1 (0.41) | ADORA1MAPK1IGF1RMAPK3MAPK14 | |
| SCHEMBL6825134 | 0.84 | ADORA1 (0.41) | ADORA1MAPK1IGF1RMAPK3MAPK14 | |
| SCHEMBL6822257 | 0.84 | ADORA1 (0.43) | ADORA1MAPK1IGF1RPDE1APDE1B | |
| SCHEMBL6818470 | 0.84 | ADORA1 (0.41) | ADORA1MAPK1IGF1RMAPK3MAPK14 | |
| SCHEMBL6825096 | 0.84 | ADORA1 (0.39) | ADORA1MAPK1IGF1RTP53POLB | |
| SCHEMBL6989388 | 0.83 | ADORA1 (0.43) | ADORA1MAPK1IGF1RTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040110763-A1 | Pyrazolopyridine compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110763-A1 | Pyrazolopyridine compound and pharmaceutical use thereof | ADRB1, ADRA1D, ADRB3 | ADORA1 22/4885MAPK1 1491/4885IGF1R 4150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.