Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | LOX | P28300 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822278 | 0.90 | P2RX3 (0.41) | UBE2NP2RX3PTGDR2PDPK1FEN1 | |
| SCHEMBL6822279 | 0.85 | TRPA1 (0.47) | P2RX3TRPA1PDPK1MMP13EPHX2 | |
| SCHEMBL6698891 | 0.84 | PTGS1 (0.41) | PTGDR2GRIN1GRIN2BMMP13PTGS1 | |
| SCHEMBL6700333 | 0.73 | S1PR3 (0.48) | TRPA1 | |
| SCHEMBL6819195 | 0.73 | LOXL2 (0.40) | LOXL2LOXTRPA1MMP13 | |
| SCHEMBL6819276 | 0.70 | GRIN1 (0.42) | TRPA1PTGDR2GRIN1GRIN2BPTGS1 | |
| SCHEMBL6703218 | 0.69 | NPSR1 (0.39) | P2RX3PTGDR2GRIN1GRIN2BMAPT | |
| SCHEMBL6702361 | 0.67 | NPSR1 (0.43) | PTGDR2GRIN1GRIN2BMAPT | |
| SCHEMBL6698004 | 0.67 | MAPT (0.41) | MMP13MAPT | |
| SCHEMBL7018972 | 0.67 | GRIN1 (0.44) | PTGDR2GRIN1GRIN2BMMP13PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014916-A1 | PYRIMIDINE FUSED BICYCLIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | claimed |
| WO-2004014916-A1 | PYRIMIDINE FUSED BICYCLIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |