Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15187637 | 0.84 | CRBN (0.52) | CRBNMAP3K14 | |
| SCHEMBL13934537 | 0.68 | CRBN (0.30) | CRBN | |
| SCHEMBL9976654 | 0.68 | CRBN (0.39) | CRBNMAP3K14 | |
| SCHEMBL14592897 | 0.67 | ALDH1A1 (0.34) | CRBN | |
| SCHEMBL8931418 | 0.67 | ALDH1A1 (0.34) | CRBN | |
| SCHEMBL14592820 | 0.67 | ALDH1A1 (0.34) | CRBN | |
| SCHEMBL24111080 | 0.67 | CRBN (0.48) | CRBNMAP3K14 | |
| SCHEMBL23351180 | 0.67 | — | — | |
| SCHEMBL2691341 | 0.66 | — | — | |
| SCHEMBL14528088 | 0.65 | CRBN (0.37) | CRBNMAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957056-B2 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTIUTE FOR CANCER RESEARCH (US) | 2015-02-17 | — | — | US | disclosed |
| US-8188141-B2 | Isomigrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110281916-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-11-17 | — | — | US | disclosed |
| US-7943800-B2 | Migrastatin analogs and uses thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-05-17 | — | — | US | disclosed |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2009-05-14 | — | — | US | disclosed |
| US-20090054488-A1 | Isomigrastatin Analogs In The Treatment Of Cancer | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054488-A1 | Isomigrastatin Analogs In The Treatment Of Cancer | EDNRB, KDR, IGF1R | CRBN 2678/4885MAP3K14 2684/4885 |
| US-20090124662-A1 | Migrastatin analogs in the treatment of cancer | MTX1, MTNR1B, MTNR1A | CRBN 3295/4885MAP3K14 3123/4885 |
| US-20110281916-A1 | MIGRASTATIN ANALOGS AND USES THEREOF | KDR, HMGCR, LPAR3 | CRBN 2072/4885MAP3K14 3198/4885 |
| US-20070037852-A1 | Migrastatin analogs and uses thereof | KDR, MTX1, FOXM1 | CRBN 2312/4885MAP3K14 2961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.