Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | F13A1 | P00488 | 2/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.34 |
| ▸ | TGM1 | P22735 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6822715 | 0.87 | USP2 (0.42) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL6823567 | 0.84 | USP2 (0.43) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL6823515 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2GPR119OPRD1OPRK1 | |
| SCHEMBL6823010 | 0.76 | USP2 (0.44) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL6823065 | 0.76 | — | — | |
| SCHEMBL31511515 | 0.76 | USP2 (0.45) | USP2SMN1; SMN2DDB1CRBNF13A1 | |
| SCHEMBL1224512 | 0.73 | USP2 (0.45) | USP2SMN1; SMN2DDB1CRBNF13A1 | |
| SCHEMBL371222 | 0.73 | USP2 (0.45) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL6823297 | 0.73 | DDB1 (0.39) | USP2SMN1; SMN2GPR119DDB1CRBN | |
| SCHEMBL31189134 | 0.72 | USP2 (0.47) | USP2SMN1; SMN2GPR119CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058763-A1 | 4(SPIROPIPERIDINYL)METHYL SUBSTITUTED PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |