Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31670530 | 0.87 | CNR2 (0.73) | CNR2NPSR1PSMD14USP2PLA2G1B | |
| SCHEMBL6824779 | 0.83 | SMYD3 (0.56) | POLBKMT2AKDM4EMAPTSMYD3 | |
| SCHEMBL12200364 | 0.79 | HTR4 (0.57) | CNR2POLBKMT2AKDM4EMAPT | |
| SCHEMBL1711760 | 0.76 | TAS1R3 (0.57) | KMT2ASMYD3NPC1RAB9AUTS2R | |
| SCHEMBL3792626 | 0.76 | NPC1 (0.56) | CNR2NPSR1PSMD14USP2PLA2G1B | |
| SCHEMBL6824522 | 0.75 | MEN1 (0.56) | KMT2ASMYD3NPC1RAB9AL3MBTL1 | |
| SCHEMBL1272484 | 0.75 | CA1 (0.71) | CA1CA2 | |
| SCHEMBL11346381 | 0.74 | NPSR1 (0.68) | NPSR1PSMD14USP2PLA2G1BALPL | |
| SCHEMBL13687260 | 0.74 | CA1 (0.66) | KDM4ELMNAGLAMAPTHTT | |
| Hydrochloric Acid SCHEMBL7527565 | 0.74 | MEN1 (0.55) | KMT2ASMYD3NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |
| CN-1132828-C | O-substd. hydroxy coumaranone derivs as antineoplastic and antitransfer agent | ROCH DIAGNOSIS EQUIPMENT AG (DE) | 2003-12-31 | — | — | CN | disclosed |
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| CN-1266850-A | O-substd. hydroxy coumaranone derivs as antineoplastic and antitransfer agent | ROCH DIAGNOSIS EQUIPMENT AG (DE) | 2000-09-20 | — | — | CN | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |