Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 17/20 | 0.46 |
| ▸ | KDR | P35968 | 15/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823529 | 0.84 | SRC (0.62) | EGFRSRCKDR | |
| SCHEMBL6819594 | 0.84 | EGFR (0.57) | EGFRSRCKDR | |
| SCHEMBL6830967 | 0.83 | SRC (0.67) | EGFRSRCKDR | |
| SCHEMBL6829449 | 0.82 | SRC (0.60) | EGFRSRCKDR | |
| SCHEMBL6823799 | 0.81 | EGFR (0.52) | EGFRSRCKDRLCKRET | |
| SCHEMBL7128347 | 0.80 | SRC (0.63) | EGFRSRCKDR | |
| Hydrochloric Acid SCHEMBL6823476 | 0.79 | SRC (0.62) | EGFRSRCKDR | |
| SCHEMBL6829415 | 0.79 | SRC (0.60) | EGFRSRCKDR | |
| SCHEMBL3194306 | 0.78 | EGFR (0.46) | EGFRSRCKDR | |
| SCHEMBL3205180 | 0.76 | SRC (0.55) | EGFRSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056812-A1 | 4- (PYRIDIN-4-YLAMINO) -QUINAZOLINE DERIVATIVES AS ANTI-TUMOR AGENTS | ASTRAZENECA AB (SE) | 2004-07-08 | — | — | WO | disclosed |