SCHEMBL6823741

SCHEMBL6823741

Cc1cc(O)ccc1OC(CC(C)N)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 4/20 0.41
OPRK1 P41145 4/20 0.41
CYP1A2 P05177 3/20 0.41
CYP3A4 P08684 3/20 0.41
CYP2D6 P10635 3/20 0.41
HTR2A P28223 3/20 0.41
HTR2B P41595 3/20 0.41
SLC6A4 P31645 3/20 0.41
SLC6A3 Q01959 3/20 0.41
CHRM1 P11229 2/20 0.41
TSHR P16473 2/20 0.41
ADRA2B P18089 2/20 0.41
HTR2C P28335 2/20 0.41
HRH1 P35367 2/20 0.41
OPRM1 P35372 2/20 0.41
DRD3 P35462 2/20 0.41
KCNH2 Q12809 2/20 0.41
KLF10 Q13118 2/20 0.41
HRH3 Q9Y5N1 2/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5285165 0.83 SLC6A2 (0.57) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL12841456 0.82 NOS2 (0.50) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL6823348 0.82 NOS2 (0.50) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL4730954 0.81 SLC6A2 (0.58) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
Oxalic Acid SCHEMBL5288252 0.80 CYP2D6 (0.51) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL30501482 0.77 SLC6A4 (0.71) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL4623634 0.77 SLC6A4 (0.71) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL8082370 0.77 SLC6A4 (0.71) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL4625001 0.76 SLC6A2 (0.71) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6
SCHEMBL9853727 0.76 ESR2 (0.44) SLC6A2OPRK1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379492-A1 INHIBITOR OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2004-01-14 EP disclosed
WO-2002070457-A1 INHIBITOR OF MONOAMINE UPTAKE ELI LILLY AND COMPANY (US) 2002-09-12 WO disclosed