Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820569 | 1.00 | HTR7 (0.55) | HTR7HTR1AMCHR1CRHR1L3MBTL1 | |
| SCHEMBL6823762 | 0.92 | HTR2A (0.45) | HTR7HTR1AMCHR1DRD4 | |
| SCHEMBL6823893 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4 | |
| SCHEMBL6823555 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4 | |
| SCHEMBL6823394 | 0.92 | HTR7 (0.45) | HTR7HTR1ADRD4 | |
| SCHEMBL6824327 | 0.88 | HTR7 (0.42) | HTR7HTR1ADRD4KCNH2 | |
| SCHEMBL6824547 | 0.88 | HTR7 (0.42) | HTR7HTR1ADRD4KCNH2 | |
| SCHEMBL6820568 | 0.83 | HTR7 (0.55) | HTR7HTR1AMCHR1L3MBTL1DRD4 | |
| SCHEMBL6824745 | 0.80 | HTR7 (0.45) | HTR7HTR1ADRD4KCNH2POLB | |
| SCHEMBL6823860 | 0.80 | UTS2R (0.49) | HTR7HTR1ADRD4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | claimed |
| WO-2004076444-A2 | NOVEL HYDROXYCOUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-10 | — | — | WO | disclosed |