Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824010 | 0.89 | KMT2A (0.50) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL7489294 | 0.84 | KMT2A (0.51) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL6920112 | 0.82 | MEN1 (0.46) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL27605657 | 0.80 | GPR35 (0.49) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL27605655 | 0.77 | GPR35 (0.41) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL6823084 | 0.74 | KMT2A (0.48) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL27605659 | 0.73 | CXCR2 (0.52) | KMT2AMEN1MAPTLMNAMAPK1 | |
| SCHEMBL27587708 | 0.72 | PKM (0.50) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL27605681 | 0.72 | NPC1 (0.54) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL27587711 | 0.71 | GPR35 (0.51) | KMT2AMAPTLMNAHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |