Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594757 | 0.88 | PLA2G4A (0.50) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL5594752 | 0.88 | PLA2G4A (0.50) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL5594749 | 0.88 | PLA2G4A (0.50) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL9632184 | 0.84 | TUBB4A (0.40) | AKR1B1KMT2AMMP2MMP9NFKB1 | |
| SCHEMBL6823440 | 0.83 | MAOA (0.51) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL6823438 | 0.83 | MAOA (0.51) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL6824218 | 0.82 | BACE1 (0.50) | AKR1B1KMT2APLA2G4AKDM4EAKR1C3 | |
| SCHEMBL14931845 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL6026164 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL6026160 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |