Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6820216 | 0.80 | KMT2A (0.46) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL27556186 | 0.78 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2MAPTMEN1GAA | |
| SCHEMBL6823553 | 0.78 | MYC (0.44) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL27653558 | 0.78 | ALDH1A1 (0.44) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL27587712 | 0.77 | MAPT (0.46) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL27587881 | 0.76 | THRB (0.41) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL6824297 | 0.76 | DAO (0.36) | KMT2ARAB9ANPC1MAPTMEN1 | |
| SCHEMBL27587711 | 0.74 | GPR35 (0.51) | KMT2ASMN1; SMN2MAPTGAAHTT | |
| SCHEMBL27556281 | 0.72 | KMT2A (0.40) | KMT2ARAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL7552627 | 0.72 | TSHR (0.36) | KMT2AMAPTMEN1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |