Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | CDC25C | P30307 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825654 | 0.89 | KDM4E (0.62) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6825043 | 0.85 | KDM4E (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6824577 | 0.76 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6825118 | 0.72 | KDM4E (0.55) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL6821955 | 0.72 | PADI4 (0.55) | KDM4EALDH1A1HPGDLMNACSF1R | |
| SCHEMBL14598935 | 0.69 | ABCG2 (0.66) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL16814644 | 0.69 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6825371 | 0.69 | MAPT (0.49) | KDM4EALDH1A1HPGDLMNAKEAP1 | |
| SCHEMBL6295684 | 0.68 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL3422670 | 0.68 | KDM4E (0.53) | KDM4EALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089930-A1 | 4-FLUOROQUINOLONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2004-10-21 | — | — | WO | disclosed |